Welcome to our
laboratory RESEARCH PAGE
Unlocking the mystery of cellular metabolism to understand and treat complex diseases
Dr. Thomas Pulinilkunnil
Associate ProfessorDepartment of Biochemistry and Molecular Biology, Dalhousie University
tpulinil@dal.ca
Nutrient regulation of lysosome metabolism, signaling and autophagy in health and disease; Amino acid biology...
Dr. Petra C. Kienesberger
Associate ProfessorDepartment of Biochemistry and Molecular Biology, Dalhousie University
pkienesb@dal.ca
My research aims to uncover the interplay among bioactive lipid signaling and cellular and organismal...
LATEST NEWS
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Congratulations to Ms Anu Jose for being awarded a DalCREW graduate studentship!
Posted by Petra August 30, 2022 Read More
Congratulations to Dr. Logan Slade for his successful PhD thesis defense!
Posted by Petra April 13, 2022 Read More
LATEST PUBLICATIONS
SEE ALLInhibiting BCKDK in triple negative breast cancer suppresses protein translation, impairs mitochondrial function, and potentiates doxorubicin cytotoxicity. Biswas D, Slade L, Duffley L, Mueller N, Dao KT, Mercer A, Pakkiriswami S, El Hiani Y, Kienesberger PC, Pulinilkunnil T. Cell Death Discov. 2021 Sep 15;7(1):241. doi: 10.1038/s41420-021-00602-0. PMID: 34526485
2021. October 6, 2021
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Whey peptides exacerbate body weight gain and perturb systemic glucose and tissue lipid metabolism in male high-fat fed mice. D’Souza K, Acquah C, Mercer A, Paudel Y, Pulinilkunnil T, Udenigwe CC, Kienesberger PC. Food Funct., 2021, Advance Article
2021. April 12, 2021
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Disrupted branched-chain amino acid catabolism impair cardiac insulin signaling and is associated with adverse cardiometabolic outcomes. BISWAS D, PULINILKUNNIL T. J Mol Cell Cardiol . 2020 Dec 27;153:93-94. doi: 10.1016/j.yjmcc.2020.12.011.
2021. February 17, 2021
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Hemodynamic Assessment and in vivo Catabolism of Adenosine 5′- Triphosphate in Doxorubicin or Isoproterenol-induced Cardiovascular Toxicity. Yeung PK, Mohammadizadeh S , Akhoundi F , Mann K , Agu RU , Pulinilkunnil T. Drug Metab Lett . 2020 Oct 21; doi: 10.2174/1872312814666201022103802. Online ahead of print.
2020. February 17, 2021
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Adverse Outcomes in Obese Cardiac Surgery Patients Correlates With Altered Branched-Chain Amino Acid Catabolism in Adipose Tissue and Heart. Biswas D, Tozer K, Dao KT, Perez LJ, Mercer A, Brown A, Hossain I, Yip AM, Aguiar C, Motawea H, Brunt KR, Shea J, Legare JF, Hassan A, Kienesberger PC, Pulinilkunnil T. Front Endocrinol (Lausanne). 2020 Aug 7;11:534. doi: 10.3389/fendo.2020.00534. eCollection 2020.
2020. September 22, 2020
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