Welcome to our
laboratory RESEARCH PAGE

Unlocking the mystery of cellular metabolism to understand and treat complex diseases

Dr. Thomas Pulinilkunnil

Associate Professor
Department of Biochemistry and Molecular Biology, Dalhousie University
tpulinil@dal.ca

Nutrient regulation of lysosome metabolism, signaling and autophagy in health and disease; Amino acid biology...

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Dr. Petra C. Kienesberger

Associate Professor
Department of Biochemistry and Molecular Biology, Dalhousie University
pkienesb@dal.ca

My research aims to uncover the interplay among bioactive lipid signaling and cellular and organismal...

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LATEST NEWS

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Congratulations to Prof. Dr. Pulinilkunnil for being the NBHRF mentor of the month February 2021!

Posted by THOMAS PULINILKUNNIL February 17, 2021

https://mailchi.mp/nbhrf.com/february2021-1432541https://mailchi.mp/nbhrf.com/february2021-1432541

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Welcome to the lab, Anu Jose!

Posted by Petra December 20, 2020

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Interviews with Dr. Thomas Pulinilkunnil *Diabetes Canada – Getting to the heart of the matter: A Q&A with one of our researchers *Dalhousie Medical Research Foundation

Posted by Petra July 7, 2020

https://www.diabetes.ca/about-diabetes/stories/getting-to-the-heart-of-the-matter–a-q-a-with-one-of-our-researchers

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Welcome to the lab, Dr. Sundaram Pakkiriswami!

Posted by Petra April 28, 2020

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We are grateful for the NSERC Discovery Grants awarded to the Pulinilkunnil and Kienesberger labs. A big thanks to all the people in the lab who made this possible.

Posted by Petra April 28, 2020

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LATEST PUBLICATIONS

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Disrupted branched-chain amino acid catabolism impair cardiac insulin signaling and is associated with adverse cardiometabolic outcomes. BISWAS D, PULINILKUNNIL T. J Mol Cell Cardiol . 2020 Dec 27;153:93-94. doi: 10.1016/j.yjmcc.2020.12.011.

2021. February 17, 2021 Read More

Hemodynamic Assessment and in vivo Catabolism of Adenosine 5′- Triphosphate in Doxorubicin or Isoproterenol-induced Cardiovascular Toxicity. Yeung PK, Mohammadizadeh S , Akhoundi F , Mann K , Agu RU , Pulinilkunnil T. Drug Metab Lett . 2020 Oct 21; doi: 10.2174/1872312814666201022103802. Online ahead of print.

2021. February 17, 2021 Read More

Adverse Outcomes in Obese Cardiac Surgery Patients Correlates With Altered Branched-Chain Amino Acid Catabolism in Adipose Tissue and Heart. Biswas D, Tozer K, Dao KT, Perez LJ, Mercer A, Brown A, Hossain I, Yip AM, Aguiar C, Motawea H, Brunt KR, Shea J, Legare JF, Hassan A, Kienesberger PC, Pulinilkunnil T. Front Endocrinol (Lausanne). 2020 Aug 7;11:534. doi: 10.3389/fendo.2020.00534. eCollection 2020.

2020. September 22, 2020 Read More

Branched-chain ketoacid overload inhibits insulin action in the muscle. Biswas D, Dao KT, Mercer A, Cowie AM, Duffley L, El Hiani Y, Kienesberger PC, Pulinilkunnil T. J Biol Chem. 2020 Nov 13; 295(46):15597-15621. doi: 10.1074/jbc.RA120.013121.

2020. September 22, 2020 Read More

Serum GDF15, a Promising Biomarker in Obese Patients Undergoing Heart Surgery. Sarkar S, Legere S, Haidl I, Marshall J, MacLeod JB, Aguiar C, Lutchmedial S, Hassan A, Brunt KR, Kienesberger P, Pulinilkunnil T, Légaré JF. Front Cardiovasc Med. 2020 Jun 24;7:103. doi: 10.3389/fcvm.2020.00103. eCollection 2020.

2020. September 21, 2020 Read More