Welcome to our
laboratory RESEARCH PAGE

Unlocking the mystery of cellular metabolism to understand and treat complex diseases

Dr. Thomas Pulinilkunnil

Associate Professor
Department of Biochemistry and Molecular Biology, Dalhousie University
tpulinil@dal.ca

Nutrient regulation of lysosome metabolism, signaling and autophagy in health and disease; Amino acid biology...

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Dr. Petra C. Kienesberger

Associate Professor
Department of Biochemistry and Molecular Biology, Dalhousie University
pkienesb@dal.ca

My research aims to uncover the interplay among bioactive lipid signaling and cellular and organismal...

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LATEST NEWS

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Interviews with Dr. Thomas Pulinilkunnil *Diabetes Canada – Getting to the heart of the matter: A Q&A with one of our researchers *Dalhousie Medical Research Foundation

Posted by Petra July 7, 2020

https://www.diabetes.ca/about-diabetes/stories/getting-to-the-heart-of-the-matter–a-q-a-with-one-of-our-researchers

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Welcome to the lab, Dr. Sundaram Pakkiriswami!

Posted by Petra April 28, 2020

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We are grateful for the NSERC Discovery Grants awarded to the Pulinilkunnil and Kienesberger labs. A big thanks to all the people in the lab who made this possible.

Posted by Petra April 28, 2020

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Come join us at the 18th Annual Meeting of the Society for Heart and Vascular Metabolism (SHVM), to be held in the vibrant and charming seaport city, Halifax, Canada, from 21 to 24 June 2020

Posted by Petra November 14, 2019

https://shvm2020.azuleon.org/welcome.php

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Congratulations to Ms. Angella Mercer for her poster prize (1st place) at the New Brunswick Health Research conference in Nov 2019!

Posted by Petra November 14, 2019

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LATEST PUBLICATIONS

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Adverse Outcomes in Obese Cardiac Surgery Patients Correlates With Altered Branched-Chain Amino Acid Catabolism in Adipose Tissue and Heart. Biswas D, Tozer K, Dao KT, Perez LJ, Mercer A, Brown A, Hossain I, Yip AM, Aguiar C, Motawea H, Brunt KR, Shea J, Legare JF, Hassan A, Kienesberger PC, Pulinilkunnil T. Front Endocrinol (Lausanne). 2020 Aug 7;11:534. doi: 10.3389/fendo.2020.00534. eCollection 2020.

2020. September 22, 2020 Read More

Branched-chain ketoacid overload inhibits insulin action in the muscle. Biswas D, Dao KT, Mercer A, Cowie AM, Duffley L, El Hiani Y, Kienesberger PC, Pulinilkunnil T. J Biol Chem. 2020 Sep 2:jbc.RA120.013121. doi: 10.1074/jbc.RA120.013121.

2020. September 22, 2020 Read More

Serum GDF15, a Promising Biomarker in Obese Patients Undergoing Heart Surgery. Sarkar S, Legere S, Haidl I, Marshall J, MacLeod JB, Aguiar C, Lutchmedial S, Hassan A, Brunt KR, Kienesberger P, Pulinilkunnil T, Légaré JF. Front Cardiovasc Med. 2020 Jun 24;7:103. doi: 10.3389/fcvm.2020.00103. eCollection 2020.

2020. September 21, 2020 Read More

Myocardial Ketones Metabolism in Heart Failure: Role of ketone in heart failure. Karwi QG, Biswas D, Pulinilkunnil T, Lopaschuk GD. J Card Fail. 2020 May 19:S1071-9164(20)30033-6. doi: 10.1016/j.cardfail.2020.04.005.

2020. June 8, 2020 Read More

Loss of function of transcription factor EB remodels lipid metabolism and cell death pathways in the cardiomyocyte. Trivedi PC, Bartlett JJ, Mercer A, Slade L, Surette M, Ballabio A, Flibotte S, Hussein B, Rodrigues B, Kienesberger PC, Pulinilkunnil T. Biochim Biophys Acta Mol Basis Dis. 2020 May 8;1866(10):165832. doi: 10.1016/j.bbadis.2020.165832.

2020. June 8, 2020 Read More