Welcome to our
laboratory RESEARCH PAGE
Unlocking the mystery of cellular metabolism to understand and treat complex diseases
Dr. Thomas Pulinilkunnil
ProfessorDepartment of Biochemistry and Molecular Biology, Dalhousie University
tpulinil@dal.ca
Nutrient regulation of lysosome metabolism, signaling and autophagy in health and disease; Amino acid biology...
Dr. Petra C. Kienesberger
ProfessorDepartment of Biochemistry and Molecular Biology, Dalhousie University
pkienesb@dal.ca
My research aims to uncover the interplay among bioactive lipid signaling and cellular and organismal...
LATEST NEWS
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Congratulations to Ms Adithi Pisapati for being awarded a DalCREW graduate studentship!
Posted by Petra August 30, 2022 Read More
Congratulations to Ms Anu Jose for being awarded a DalCREW graduate studentship!
Posted by Petra August 30, 2022 Read More
Congratulations to Ms. Gurpreet Kaur on her successful MSc thesis defense!
Posted by Petra September 11, 2025 Read More
Congratulations to Maggie Pickard on her successful MSc thesis defence!
Posted by Petra May 20, 2023 Read More
LATEST PUBLICATIONS
SEE ALLLowering Cardiac Branched-Chain Keto Acid Levels Enhances Cardiac Glucose Oxidation and Cardiac Efficiency via Enhancing Mitochondrial Insulin Signaling in Heart Failure. Karwi QG, Zhang L, Gopal K, Wagg CS, Ho KL, Sun Q, Panidarapu S, Persad K, Altuany B, Damen S, Ketema E, Levasseur J, Pulinilkunnil T, Ussher JR, Dyck JRB, Lopaschuk GD. Circ Heart Fail. 2025 Jul 25:e012012. doi: 10.1161/CIRCHEARTFAILURE.124.012012. Epub ahead of print. PMID: 40709461.
2025. August 22, 2025
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Effect of cardiomyocyte-specific lipid phosphate phosphatase 3 overexpression on high-fat diet-induced cardiometabolic dysfunction in mice. ose A, Pakkiriswami S, Mercer A, Paudel Y, Yi E, Fernando J, Pulinilkunnil T, Kienesberger PC. Am J Physiol Heart Circ Physiol. 2025 Feb 1;328(2):H333-H347. doi: 10.1152/ajpheart.00518.2024. Epub 2025 Jan 13. PMID: 39805037.
2025. August 22, 2025
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Targeting TRPML3 inhibits proliferation and invasion, and enhances doxorubicin sensitivity by disrupting lysosomal acidification and mitochondrial function in triple-negative breast cancer. Gomes GMA, Xu M, Syeda AKR, Raudonis R, Almasi S, Vijayan VV, Gujar S, Dong X, Cheng Z, Pulinilkunnil T, El Hiani Y. Biochim Biophys Acta Mol Cell Res. 2025 Aug;1872(6):119979. doi: 10.1016/j.bbamcr.2025.119979. Epub 2025 May 8. PMID: 40348344.
2025. August 22, 2025
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The Terry Fox Research Institute Marathon of Hope Cancer Centres Network: A pan-Canadian precision oncology initiative. Terry Fox Research Institute Marathon of Hope Cancer Centers Network. Electronic address: mmarra@bcgsc.ca; Terry Fox Research Institute Marathon of Hope Cancer Centers Network. Cancer Cell. 2025 Apr 14;43(4):587-592. doi: 10.1016/j.ccell.2025.03.014. Epub 2025 Apr 3. PMID: 40185094.
2025. August 22, 2025
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Effect of (poly)phenol-rich ‘Daux Belan’ apple supplementation on diet-induced obesity and glucose intolerance in C57BL/6NCrl mice. Yu CHJ, Kienesberger PC, Pulinilkunnil T, Rupasinghe HPV. Sci Rep. 2023 Oct 11;13(1):17206. doi: 10.1038/s41598-023-43687-6. PMID: 37821510; PMCID: PMC10567707.
2023. August 22, 2025
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