Welcome to our
laboratory RESEARCH PAGE

Unlocking the mystery of cellular metabolism to understand and treat complex diseases

Dr. Thomas Pulinilkunnil

Professor
Department of Biochemistry and Molecular Biology, Dalhousie University
tpulinil@dal.ca

Nutrient regulation of lysosome metabolism, signaling and autophagy in health and disease; Amino acid biology...

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Dr. Petra C. Kienesberger

Associate Professor
Department of Biochemistry and Molecular Biology, Dalhousie University
pkienesb@dal.ca

My research aims to uncover the interplay among bioactive lipid signaling and cellular and organismal...

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LATEST NEWS

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Congratulations to Ms. Anu Jose on her successful MSc thesis defense!

Posted by Petra June 15, 2023

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Congratulations to Ms Adithi Pisapati for being awarded a DalCREW graduate studentship!

Posted by Petra August 30, 2022

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Congratulations to Ms Anu Jose for being awarded a DalCREW graduate studentship!

Posted by Petra August 30, 2022

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A hearty welcome to the summer students, Tia Augustine (NBHRF funded), Gurpreet Kaur (NBHRF funded) and Sarah Godin (Mitacs Globalink funded)! We look forward to working with you this summer.

Posted by Petra May 20, 2023

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Congratulations to Maggie Pickard on her successful MSc thesis defence!

Posted by Petra May 20, 2023

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Congratulations to Dr. Logan Slade on his graduation!

Posted by Petra November 23, 2022

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LATEST PUBLICATIONS

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Loss of transcription factor EB dysregulates the G1/S transition and DNA replication in mammary epithelial cells. Slade L, Biswas D, Kienesberger PC, Pulinilkunnil T. J Biol Chem. 2022;298(12):102692. doi: 10.1016/j.jbc.2022.102692. PMID: 36372230

2022. May 9, 2023 Read More

Nanoparticle surface-enhanced Raman spectroscopy as a noninvasive, label-free tool to monitor hematological malignancy. Grieve S, Puvvada N, Phinyomark A, Russell K, Murugesan A, Zed E, Hassan A, Legare JF, Kienesberger PC, Pulinilkunnil T, Reiman T, Scheme E, Brunt KR. Nanomedicine (Lond).16(24):2175-2188. doi: 10.2217/nnm-2021-0076. PMID: 34547916

2021. May 9, 2023 Read More

Inhibiting BCKDK in triple negative breast cancer suppresses protein translation, impairs mitochondrial function, and potentiates doxorubicin cytotoxicity. Biswas D, Slade L, Duffley L, Mueller N, Dao KT, Mercer A, Pakkiriswami S, El Hiani Y, Kienesberger PC, Pulinilkunnil T. Cell Death Discov. 2021 Sep 15;7(1):241. doi: 10.1038/s41420-021-00602-0. PMID: 34526485

2021. October 6, 2021 Read More

Whey peptides exacerbate body weight gain and perturb systemic glucose and tissue lipid metabolism in male high-fat fed mice. D’Souza K, Acquah C, Mercer A, Paudel Y, Pulinilkunnil T, Udenigwe CC, Kienesberger PC. Food Funct., 2021, Advance Article

2021. April 12, 2021 Read More

Disrupted branched-chain amino acid catabolism impair cardiac insulin signaling and is associated with adverse cardiometabolic outcomes. BISWAS D, PULINILKUNNIL T. J Mol Cell Cardiol . 2020 Dec 27;153:93-94. doi: 10.1016/j.yjmcc.2020.12.011.

2021. February 17, 2021 Read More