Cardiac complications of congenital disorders of glycosylation (CDG): a systematic review of the literature. Marques-da-Silva D, Francisco R, Webster D, Dos Reis Ferreira V, Jaeken J, Pulinilkunnil T. J Inherit Metab Dis. 2017 Sep;40(5):657-672.
Congenital disorders of glycosylation (CDG) areinborn errors of metabolism due to protein and lipidhypoglycosylation. This rapidly growing family of geneticdiseases comprises 103 CDG types, with a broad phenotypicdiversity ranging from mild to severe poly-organ -system dys-function. This literature review summarizes cardiac involve-ment, reported in 20{8617e24ab0b76aabcd10cf8004a7bdc562123dc1ea8adc37299158a7c05423e6} of CDG. CDG with cardiac involve-ment were divided according to the associated type of glyco-sylation: N-glycosylation, O-glycosylation, dolichol synthe-sis, glycosylphosphatidylinositol (GPI)-anchor biosynthesis,COG complex, V-ATPase complex, and other glycosylationpathways. The aim of this review was to document and inter-pret the incidence of heart disease in CDG patients. Heartdisorders were grouped into cardiomyopathies, structural de-fects, and arrhythmogenic disorders. This work may contrib-ute to improved early management of cardiac complications inCDG